Table 4.

Pharmacokinetics of dasatinib

Dose level	Date	N	Cmax (ng/mL)	AUC(0-T) (ng.h/mL)	Tmax (h)	T-HALF (h)
			Geomean (%CV)	Geomean (%CV)	Med (Min, Max)	Mean (SD)
100 mg	Day 0	3	101.0 (40.5)	475.9 (61.3)	1.0 (0.5, 4.0)	6.8 (0.1)
	Day 15	3	165.5 (73.4)	663.6 (65.1)	0.5 (0.5, 5.0)	6.4 (0.1)
150 mg	Day 0	18	144.0 (58.5)	594.0 (45.3)	1.5 (0.5, 4.0)	5.2 (1.0)
	Day 15	18	145 (77.4)	621.2 (52.9)	2.0 (0.5, 5.0)	5.7 (1.)
200 mg	Day 0	3	414.7 (63.0)	1448 (30.1)	1.0 (0.5, 3.0)	5.1 (0.6)
	Day 15	0	NA	NA	NA	NA