Figure 3. AR expression is not directly modulated in vivo in response to doxycycline induction of activated AKT.

(A) AR and pAKT expression in ventral prostate from double transgenic mice induced or uninduced for 8 weeks. (B) AR and pAKT staining in serial sections of ventral prostate from double transgenic mice treated with doxycycline for 2, 4, or 7 days. Sections shown are representative of ventral prostates from at least 3 mice at each time. Arrows indicate examples of cells with large nuclei and lower AR that are not in contact with basal layer.