Table 3. Antimicrobial testing of NlysNlysNlys based lipopeptoids.
Compound Organism | CTAC | C11-NlysNlysNlys | C14-NlysNlysNlys | C16-NlysNlysNlys | C20-NlysNlysNlys | F11-NlysNlysNlys | C11-NhargNhargNharg | C14-NhargNhargNharg | C16-NhargNhargNharg | C20-NhargNhargNharg |
S.aureus b | 1 | 512 | 32 | 16 | 16 | 32 | 128 | 16 | 8 | 8 |
MRSA c | 1 | 512 | 64 | 32 | 16 | 32 | 128 | 16 | 16 | 16 |
MSSE d | 0.5 | 512 | 32 | 8 | 8 | 32 | 64 | 8 | 8 | 8 |
MRSE e | 2 | 512 | 16 | 8 | 8 | 32 | 256 | 16 | 8 | 8 |
E. faecalis f | 1 | 512 | 64 | 32 | 16 | 64 | 512 | 32 | 16 | 16 |
E. faecium g | 0.5 | 256 | 64 | 32 | 16 | 64 | 256 | 16 | 16 | 8 |
S.pneumoniae h | 2 | >512 | 128 | 128 | 64 | 128 | 512 | 64 | 64 | 64 |
E.coli i | 16 | >512 | 128 | 32 | 32 | 64 | >512 | 64 | 16 | 64 |
E.coli j | 32 | >512 | 128 | 64 | 32 | 64 | >512 | 64 | 32 | 64 |
E.coli k | 16 | >512 | 128 | 64 | 32 | 128 | >512 | 64 | 32 | 32 |
P.aeruginosa l | 128 | >512 | 512 | 128 | 128 | 128 | >512 | 256 | 64 | 128 |
P.aeruginosa m | 64 | >512 | 512 | 128 | 64 | 256 | >512 | 128 | 64 | 128 |
S. maltophilia n | 32 | >512 | >512 | 256 | 64 | >512 | >512 | 256 | 128 | 64 |
A. baumannii o | 32 | >512 | 512 | 256 | 64 | >512 | >512 | 256 | 128 | 64 |
K.pneumoniae p | 16 | >512 | 512 | 128 | 64 | >512 | >512 | 256 | 256 | 64 |
Haemolysis | 77.05 | 0.67 | 2.19 | 67.69 | 68.29 | 8.13 | 0.71 | 20.34 | 30.80 | 71.50 |
MIC, reported in µg/mL.
ATCC 29213.
ATCC 33592.
81388 CANWARD 2008.
CAN-ICU 61589.
ATCC 29212.
ATCC 27270.
ATCC 49619.
ATCC 25922.
CAN-ICU 61714.
CAN-ICU 63074.
ATCC 27853.
CAN-ICU 62308.
CAN-ICU 62584.
CAN-ICU 63169.
ATCC 13883.
Percent haemolysis at 100µg/mL of compound.