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. 2012 Feb 1;185(3):267–274. doi: 10.1164/rccm.201107-1281OC

TABLE 1.

CLINICAL CHARACTERISTICS OF INDIVIDUALS WITH ASTHMA AND HEALTHY CONTROLS

Normal Mild–Moderate Asthma (GINA 1–3) Severe Asthma (GINA 4–5)
Number 9 18 10
Age* 42 (5) 49 (4) 53 (3)
Male/female 5/4 7/11 4/6
Never/current/ex-smokers 8/1/0 14/4/0 7/3/0
Atopy, n (%) 4 (44) 12 (67) 7 (70)
PC20FEV1, mg/ml >16 0.46 (0.17–1.3) 0.78 (0.26–2.3)
FEV1, % predicted* 94 (3) 82 (7) 77 (7)
Pre-BD FEV1/FVC, %* 82 (2) 72 (2) 69 (5)
BD response, %* 0 (0) 11 (4) 11 (3)
Sputum cell counts
 TCC* 0.9 (0.1) 2.4 (0.5) 4.7 (1.1)
 Eosinophil, %§ 0.4 (0.8) 1.0 (5.2) 4.6 (13.3)
 Neutrophil, %* 56 (12) 48 (7) 62 (8)
 Macrophage, %* 37 (12) 39 (7) 26 (6)
 Lymphocyte, %* 2.0 (1.5) 1.2 (0.3) 0.8 (0.4)
 Epithelial cells, %* 5 (4) 6 (1) 2 (1)
8-oxodG semiquantitative score
 Epithelium§ 4.5 (1.25) 5 (0.5) 5 (0.75)
 Lamina propria§ 4 (1) 5 (0.75) 5 (0.75)
 Airway smooth muscle§ 2 (2.25) 4.5 (1.75) 4.5 (2)

Definition of abbreviations: BD = bronchodilator; GINA = Global Initiative for Asthma; 8-oxodG = 8-oxo-7,8-dihydro-2′-deoxyguanosine; TCC = total cell count.

*

Mean (SEM).

Geometric mean (95% confidence interval).

P < 0.05 compared to control.

§

Median (interquartile range).