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The 5-HTRs binding profile of sorafenib.
| Receptor | 5-HT1A | 5-HT2A | 5-HT2B | 5-HT2C | 5-HT5a | 5-HT6 | 5-HT7 |
|---|---|---|---|---|---|---|---|
| Ki (nM) | 1,181 | 1,959 | 56.0 | 417.0 | 3,296 | 6,213 | 7,071 |
Note that data represent Ki (nM) values obtained from non-linear regression of radioligand competition binding isotherms. Ki values are calculated from best fit IC50 values using the Cheng-Prusoff equation.
