. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Am J Med Genet A. 2012 Jun 18;158A(8):2071–2090. doi: 10.1002/ajmg.a.35438

Table VIII.

Epidemiological studies concerning Gabapentin monotherapy during pregnancy and the risk of birth defects

Authors	Study Methodology	n	Rate of MCM	OR/RR (95% CI)
Montouris 2003	Prospective and Retrospective	17	5.9%	NA
Morrow 2006	Prospective	31	3.2%	OR 1.33 (0.17 - 10.20)
Vajda 2007	Prospective	11	0%	NA
Holmes 2008	Prospective	127	0.8%	NA
Vajda 2010	Retrospective	14	0%	NA

RR—relative risk, OR—odds ratio, CI-Confidence Interval, NA—data not available Updated from [Hill et al., 2010. Teratogenic effects of antiepileptic drugs. Expert Rev Neurother 10(6):943-59.]