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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Magn Reson Imaging. 2012 May 1;30(7):1002–1009. doi: 10.1016/j.mri.2012.02.015

Figure 4. The effect of treatment on vascular permeability (Ktrans).

Figure 4

The average Ktrans of the tumor was measured with Dynamic Contrast Enhancement MRI. Error bars represent the standard deviation of cohorts of 5 to 7 mice. Statistically significant differences relative to the same cohort at Day -1 are indicated by asterisks (*, p< 0.05; **, p< 0.01). A) The median value of Ktrans and B) the relative changes in median Ktrans values showed that TH-302 caused a significant decrease in Ktrans relative to vehicle after one day of treatment, but not after eight days of treatment.