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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Invest Dermatol. 2012 May 10;132(8):2067–2075. doi: 10.1038/jid.2012.112

Figure 3.

Figure 3

Aortic root vascular inflammation develops in the presence of elevated systemic inflammation and monocytosis and independent of lower lipid levels. Proinflammatory cytokines are significantly elevated in KC-Tie2 mouse sera, including levels of MCP-1, IL-12p70, TNFα, IL-17A and VEGF (a; mean ± SEM; n=5–11 per group) and S100A8/A9 expression is increased in skin and serum of KC-Tie2 animals (b). KC-Tie2 animals have significantly less total cholesterol, triglycerides and HDL compared to control mice (c; mean ± SEM; n=8 per group; p values indicated for each lipid in table). 4-colour flow cytometry reveals significant increases in splenic proatherogenic monocytes (CD90loB220loCD49bloNK1.1loLy6GloCD11cloIAbloF4/80loCD11bhiLy-6Chi). Representative flow cytometry and quantification of CD11b+F4/80loLy-6Chi cells (d; mean ± SEM; n =4 spleens per group).* P <0.05 vs. control animals.