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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Invest Dermatol. 2012 May 10;132(8):2067–2075. doi: 10.1038/jid.2012.112

Figure 5.

Figure 5

Repressing skin inflammation improves aortic root lesions and thrombosis clotting times. Seven month old KC-Tie2 mice (n=9) and control littermates (n=9) were treated with doxycycline to repress transgene expression and reverse skin inflammation. Aortic roots from representative 1 year old control (a, c, e) and KC-Tie2 (b, d, f) animals stained with H&E (a–b), Trichrome (c–d) and elastin (e–f). No aortic root lesions were observed in any control or KC-Tie2 doxycycline treated mice. (g) KC-Tie2 and control mice treated with doxycycline for 6 weeks underwent experimental thrombosis; mean time (± SEM) to occlusive thrombus formation was not significantly different between control mice treated with doxycycline (31 ± 8 minutes; n=10) and KC-Tie2 mice treated with doxycycline (36 ± 9 minutes; n=10; P=0.69). Scale bar = 100 μm.