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Coffin-Siris diagnostic algorithm. DD = developmental delay; CD = cognitive delay; CSS = Coffin-Siris syndrome; BOD = brachymorphism-onychodysplasia-dysphalangism; DOOR = deafness, onychodystrophy, osteoodystrophy, and mental retardation; NCBRS = Nicolaides-Baraitser syndrome; CdLS = Cornelia de Lange syndrome
