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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Mol Neurosci. 2012 Mar 3;48(2):347–356. doi: 10.1007/s12031-012-9728-2

Fig. 2.

Fig. 2

(A) Neuroprotective role of pGlu-Serpinin against Staurosporine (STS) in primary cultured rat hippocampal neurons. Primary E18 rat hippocampal neurons were cultured for 5 days. Then neurons were treated with 10 nM pGlu-serpinin or vehicle for 24 h. Subsequently, cytotoxicity was induced by 200 nM STS. Lactic acid dehydrogenase release assay was used to determine cytotoxicity after 24 h treatment of cells with STS. **p<0.01 (t-test). (B) pGlu-serpinin up-regulated Bcl-2 mRNA expression after H2O2. - induced oxidative stress. Primary E 18 rat cortical neurons were cultured for 5 days. and then treated with 10 nM pGlu-serpinin or vehicle for 24 h. Neurons were then treated with 50 μM H2O2. to induce cell death. 24 h later, the neurons were collected for qPCR assay to assess the mRNA level of bcl-2 in different groups. **p<0.01 (t-test).