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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Dev Biol. 2012 May 8;368(2):181–192. doi: 10.1016/j.ydbio.2012.04.034

Figure 8. A model for the cell-autonomous requirement of ZFH1, Chinmo, and Ken in CySCs to prevent differentiation.

Figure 8

Upd from the hub activates the JAK-STAT signaling pathway in adjacent GSCs and CySCs. In CySCs, activation of Stat92E leads to expression of its targets ZFH1 and Chinmo, which are both required for CySCs self-renewal. Similarly, Ken is cell-autonomously required for CySC self-renewal in a Stat92E-independent manner. Stat92E activates Socs36E and represses Ptp61F expression. Whether Ptp61F behaves as an inhibitor of Stat92E in the testis remains unknown (dashed line). See text for details.