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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Dev Biol. 2012 Jun 7;368(2):312–322. doi: 10.1016/j.ydbio.2012.05.034

Fig. 7. Model for requirement of Na,K-ATPase during brain ventricle development.

Fig. 7

(A) Brain ventricle development is a three step process that requires establishment of neuroepithelial polarity and junctions and regulation of neuroepithelial permeability allowing for CSF retention, in addition to CSF production. Brain ventricle inflation occurs via CSF retention and CSF production. (B) Neuroepithelial formation requires RhoA which acts downstream of Fxyd1 and Atp1a1. (C) Neuroepithelial permeability requires RhoA which acts downstream of only Atp1a1. (D) CSF production is RhoA - insensitive and requires Atp1a1.