Table 1. Correlation of sensitivity to PAB to β-tubulin isotype content in 12 cultured human cancer cell lines.
| Tumor type Cell line | βI | βII | βIII | βIVa+b | Paclitaxela | Vinblastinea | PABb |
|---|---|---|---|---|---|---|---|
| Relative amount of β-tubulin isotype (%)a | - - - - - - - - - - - - - - - -IC50 (nM) - - - - - - - - - - - - - - - - | ||||||
| Colon carcinoma | |||||||
| COLO-205 | 36.0 | 0 | 0 | 64.0 | 28 | 0.7 | 850 ± 70 |
| HCT-15 | 61.8 | 0 | 0.2 | 38.0 | 4.6 | 28 | 530 ± 100 |
| Breast carcinoma | |||||||
| BT-549 | 65.9 | 0.6 | 6.4 | 27.1 | 4.9 | 1.1 | 440 ± 200 |
| T-47D | 85.7 | 0 | 0 | 14.3 | 1.5 | 9.3 | 490 ± 10 |
| MCF-7 | 39.1 | 0 | 2.5 | 58.4 | 1.0 | 0.4 | 550 ± 70 |
| MDA-MB-231 | 76.1 | 0 | 0 | 23.9 | 0.4 | 1.6 | 260 ± 60 |
| Lung carcinoma | |||||||
| A-549 | 71.9 | 0 | 1.6 | 26.5 | 2.7 | 1.7 | 1,100 ± 200 |
| HOP-18 | 63.2 | 1.5 | 5.0 | 30.3 | 0.7 | 0.5 | 1,200 ± 300 |
| Melanoma | |||||||
| MALME-3M | 84.4 | 3.8 | 5.1 | 7.0 | 4.4 | 0.7 | 420 ± 50 |
| SK-MEL-2 | 73.1 | 1.4 | 1.5 | 24.0 | 3.9 | 0.9 | 330 ± 40 |
| Ovarian carcinoma | |||||||
| OVCAR-3 | 97.0 | 0 | 0 | 3.1 | 1.5 | 2.5 | 610 ± 7 |
| SK-OV-3 | 85.6 | 0 | 0.8 | 13.6 | 3.3 | 1.6 | 1,200 ± 40 |
a
Data from ref. 27.
b
Average of at least two determinations ± standard deviation.