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. Author manuscript; available in PMC: 2013 Jul 27.
Published in final edited form as: Transplantation. 2012 Jul 27;94(2):114–122. doi: 10.1097/TP.0b013e3182584879

Figure 5. PFD inhibits p38 MAPK phosphorylation.

Figure 5

The effect of PFD on MAPK activation was measured using the p38 and JNK cell- based assay. Isolated DCs with or without 2mM PFD for 72 hours were stimulated with 1µg/ml LPS and p38 MAPK and JNK phosphorylation measured at 0, 10, 30, and 60 minutes. DCs stimulated with LPS showed an increase in both p38 and JNK phosphorylation while PFD treated DCs demonstrated a decrease in p38 MAPK phosphorylation at 30 and 60 min but there was no effect on the JNK phosphorylation. ** Represents p value < 0.05 (n = 3 independent experiments) for LPS versus LPS plus PFD treated DCs.