. Author manuscript; available in PMC: 2013 Sep 15.

Published in final edited form as: Int J Cancer. 2012 Apr 30;131(6):E1038–E1043. doi: 10.1002/ijc.27592

Table 2.

Association^* of selected genetic risk variants for obesity with colorectal cancer, overall and by BMI level

Gene	SNP	Genotype	Combined		By Obesity Level
			Combined		BMI < 30	P	BMI ≥ 30	P	P-het
			OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	P-het
FTO	rs1121980	GG	1.0 (reference)		1.0 (reference)		1.0 (reference)
		GA	1.09 (0.96, 1.23)	0.18	1.14 (0.99, 1.32)	0.06	0.86 (0.66, 1.13)	0.28
		AA	1.08 (0.90, 1.29)	0.40	1.21 (0.98, 1.49)	0.08	0.68 (0.47, 0.98)	0.04
		trend	1.05 (0.97, 1.14)	0.24	1.11 (1.01, 1.22)	0.04	0.84 (0.70, 0.99)	0.04	0.005

FTO	rs1421085	TT	1.0 (reference)		1.0 (reference)		1.0 (reference)
		TC	0.98 (0.86, 1.10)	0.69	1.01 (0.88, 1.16)	0.88	0.82 (0.63, 1.06)	0.13
		CC	0.99 (0.79, 1.24)	0.93	1.04 (0.80, 1.34)	0.80	0.78 (0.49, 1.23)	0.28
		trend	0.99 (0.90, 1.08)	0.77	1.02 (0.92, 1.13)	0.71	0.84 (0.70, 1.01)	0.07	0.07

FTO	rs1558902	TT	1.0 (reference)		1.0 (reference)		1.0 (reference)
		TA	0.94 (0.83, 1.06)	0.30	0.97 (0.85, 1.12)	0.72	0.81 (0.61, 1.06)	0.13
		AA	1.02 (0.81, 1.28)	0.85	1.07 (0.82, 1.39)	0.63	0.82 (0.51, 1.32)	0.42
		trend	0.98 (0.89, 1.07)	0.63	1.01 (0.91, 1.13)	0.79	0.84 (0.69, 1.01)	0.07	0.08

FTO	rs3751812	GG	1.0 (reference)		1.0 (reference)		1.0 (reference)
		GT	0.96 (0.87, 1.07)	0.50	0.99 (0.88, 1.12)	0.89	0.84 (0.67, 1.06)	0.14
		TT	0.99 (0.80, 1.21)	0.90	1.04 (0.82, 1.32)	0.77	0.77 (0.50, 1.18)	0.23
		trend	0.98 (0.90, 1.06)	0.61	1.01 (0.92, 1.11)	0.82	0.84 (0.71, 1.00)	0.05	0.06

FTO	rs8050136	CC	1.0 (reference)		1.0 (reference)		1.0 (reference)
		CA	1.04 (0.93, 1.16)	0.47	1.08 (0.95, 1.22)	0.24	0.89 (0.70, 1.12)	0.31
		AA	1.04 (0.87, 1.24)	0.64	1.17 (0.95, 1.44)	0.14	0.70 (0.49, 0.99)	0.04
		trend	1.03 (0.95, 1.11)	0.49	1.08 (0.99, 1.19)	0.08	0.84 (0.72, 0.99)	0.03	0.006

FTO	rs9930506	AA	1.0 (reference)		1.0 (reference)		1.0 (reference)
		AG	1.07 (0.95, 1.21)	0.28	1.14 (0.99, 1.31)	0.06	0.89 (0.68, 1.16)	0.38
		GG	1.03 (0.85, 1.26)	0.75	1.08 (0.86, 1.37)	0.51	0.83 (0.55, 1.26)	0.38
		trend	1.04 (0.95, 1.13)	0.43	1.08 (0.99, 1.20)	0.12	0.88 (0.73, 1.05)	0.16	0.04

FTO	rs9939609	TT	1.0 (reference)		1.0 (reference)		1.0 (reference)
		TA	1.03 (0.91, 1.16)	0.68	1.05 (0.91, 1.21)	0.51	0.89 (0.68, 1.17)	0.40
		AA	1.03 (0.85, 1.24)	0.78	1.17 (0.94, 1.46)	0.16	0.64 (0.44, 0.95)	0.02
		trend	1.02 (0.93, 1.11)	0.70	1.06 (0.96, 1.17)	0.23	0.84 (0.71, 1.01)	0.06	0.02

FTO	rs9941349	CC	1.0 (reference)		1.0 (reference)		1.0 (reference)
		CT	1.02 (0.92, 1.13)	0.75	1.07 (0.95, 1.20)	0.29	0.87 (0.68, 1.07)	0.17
		TT	1.02 (0.84, 1.23)	0.86	1.07 (0.87, 1.32)	0.57	0.81 (0.57, 1.18)	0.27
		trend	1.01 (0.94, 1.09)	0.76	1.05 (0.96, 1.15)	0.25	0.86 (0.73, 1.01)	0.06	0.03

KCTD15	rs11084753	AA	1.0 (reference)		1.0 (reference)		1.0 (reference)
		AG	0.92 (0.80, 1.05)	0.21	0.95 (0.81, 1.11)	0.49	0.80 (0.59, 1.08)	0.14
		GG	0.88 (0.75, 1.02)	0.10	0.94 (0.78, 1.12)	0.49	0.68 (0.49, 0.94)	0.02
		trend	0.94 (0.87, 1.01)	0.10	0.99 (0.91, 1.09)	0.89	0.77 (0.66, 0.90)	0.0008	0.004

KCTD15	rs29941	TT	1.0 (reference)		1.0 (reference)		1.0 (reference)
		TC	0.86 (0.75, 1.00)	0.045	0.89 (0.76, 1.05)	0.17	0.68 (0.49, 0.95)	0.02
		CC	0.81 (0.68, 0.96)	0.01	0.90 (0.74, 1.09)	0.27	0.54 (0.38, 0.78)	0.001
		trend	0.90 (0.83, 0.98)	0.01	0.97 (0.88, 1.06)	0.49	0.70 (0.60, 0.82)	<0.0001	0.0003

MC4R	rs17782313	TT	1.0 (reference)		1.0 (reference)		1.0 (reference)
		TC	1.10 (0.98, 1.23)	0.10	1.07 (0.94, 1.23)	0.29	1.18 (0.92, 1.50)	0.19
		CC	1.28 (1.01, 1.61)	0.04	1.31 (1.00, 1.70)	0.05	1.15 (0.69, 1.92)	0.60
		trend	1.12 (1.02, 1.22)	0.02	1.10 (1.00, 1.22)	0.06	1.16 (0.97, 1.41)	0.11	0.61

Odds ratios (ORs) and 95% confidence intervals (CIs) estimated in logistic regression models that adjusted for age and ethnicity, and also sex for the obesity-stratification. P-het.: P-values for heterogeneity by sex or BMI (<30 or ≥ 30).