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. Author manuscript; available in PMC: 2013 Sep 6.
Published in final edited form as: Neuroscience. 2012 May 26;219:183–191. doi: 10.1016/j.neuroscience.2012.05.048

Figure 7. Inhibition of sEH using 4-PCO does not alter the difference in sensitivity to OGD between cells from males vs. females.

Figure 7

On day 10 in vitro, cultured cortical neurons from males and females were treated with 4-Phenylchalcone oxide (4-PCO, 2 µM), an inhibitor of the hydrolase activity of soluble epoxide hydrolase, or vehicle (DMSO). Treatment was initiated 1 hour prior to OGD and continued throughout OGD and 24 hours of reoxygenation. Cells from females were more resistant to cell death in both vehicle and 4-PCO treated cells as expressed relative to the mean in cells from males (n=5, *p<0.05).