Table 3.
Association between BMI change and lung cancer, stratified by risk factors.
| <−5% (weight loss) |
−5% to <+5% | 5% to <25% | ≥25% | P trend** | |
|---|---|---|---|---|---|
| BMI at age 21* (kg/m2) | |||||
| Tertile 1 | |||||
| case/controls | 5/1 | 39/36 | 90/137 | 102/169 | |
| Adj OR (95% CI)1 | 2.22 (0.21, 22.88) | 1.00 | 0.63 (0.33, 1.22) | 0.41 (0.21, 0.80) | 0.005 |
| Tertile 2 | |||||
| case/controls | 21/8 | 32/51 | 81/174 | 53/113 | |
| Adj OR (95% CI) 1 | 2.64 (0.89, 7.78) | 1.00 | 0.87 (0.46, 1.64) | 0.63 (0.32, 1.25) | 0.161 |
| Tertile 3 | |||||
| case/controls | 25/30 | 42/52 | 74/159 | 34/93 | |
| Adj OR (95% CI) 1 | 0.60 (0.24, 1.45) | 1.00 | 0.64 (0.33, 1.23) | 0.47 (0.22, 1.00) | 0.042 |
| Tobacco Smoking Status | |||||
| Never | |||||
| case/controls | 4/12 | 10/70 | 54/224 | 37/176 | |
| Adj OR (95% CI)2 | 1.59 (0.36, 7.02) | 1.00 | 1.45 (0.66, 3.19) | 1.11 (0.49, 2.54) | 0.787 |
| Former | |||||
| case/controls | 30/15 | 63/42 | 142/168 | 120/132 | |
| Adj OR (95% CI) 2 | 1.60 (0.72, 3.54) | 1.00 | 0.67 (0.41, 1.08) | 0.54 (0.33, 0.90) | 0.017 |
| Current | |||||
| case/controls | 17/12 | 40/27 | 49/78 | 32/67 | |
| Adj OR (95% CI) 2 | 0.81 (0.31, 2.10) | 1.00 | 0.40 (0.21, 0.78) | 0.28 (0.13, 0.57) | 0.001 |
| Alcohol Drinking Status | |||||
| Never | |||||
| case/controls | 11/14 | 25/33 | 66/100 | 61/109 | |
| Adj OR (95% CI)3 | 0.77 (0.24, 2.47) | 1.00 | 1.12 (0.53, 2.38) | 0.68 (0.31, 1.49) | 0.173 |
| Former | |||||
| case/controls | 21/10 | 51/26 | 104/83 | 70/78 | |
| Adj OR (95% CI) 3 | 0.76 (0.25, 2.24) | 1.00 | 0.69 (0.35, 1.36) | 0.43 (0.21, 0.89) | 0.017 |
| Current | |||||
| case/controls | 19/15 | 37/79 | 74/286 | 58/187 | |
| Adj OR (95% CI) 3 | 1.63 (0.62, 4.29) | 1.00 | 0.62 (0.35, 1.09) | 0.48 (0.26, 0.88) | 0.021 |
| Tobacco Smoking Pack-years | |||||
| <20 | |||||
| case/controls | 10/15 | 10/48 | 44/163 | 33/120 | |
| Adj OR (95% CI)2 | 2.07 (0.65, 6.63) | 1.00 | 1.24 (0.54, 2.84) | 0.78 (0.32, 1.90) | 0.328 |
| ≥20 | |||||
| case/controls | 37/12 | 93/21 | 147/83 | 119/79 | |
| Adj OR (95% CI)2 | 0.74 (0.31, 1.73) | 1.00 | 0.37 (0.21, 0.67) | 0.25 (0.13, 0.45) | <0.001 |
|
Time Since Quitting Tobacco
Smoking |
|||||
| ≤ 3 years | |||||
| case/controls | 23/7 | 50/8 | 93/24 | 71/17 | |
| Adj OR (95% CI)2 | 0.53 (0.13, 2.16) | 1.00 | 1.16 (0.41, 3.27) | 0.65 (0.22, 1.91) | 0.300 |
| >3 years | |||||
| case/controls | 7/8 | 13/34 | 49/144 | 49/115 | |
| Adj OR (95% CI)2 | 1.34 (0.35, 5.10) | 1.00 | 0.89 (0.40, 1.96) | 0.78 (0.35, 1.75) | 0.478 |
1
Adjusted for age, gender, ethnicity, tobacco smoking status, pack-years, education, calories.
2
Adjusted for age, gender, ethnicity, education, calories.
3
Adjusted for age, gender, ethnicity, tobacco smoking status, pack-years, education, calories.
*
Tertile 1 <20.96, Tertile 2 from 20.96 to <23.56, Tertile 3 ≥23.56
**
Negative BMI change (weight loss) excluded.
Adj: Adjusted, BMI: Body Mass Index, SCC: Squamous Cell Carcinoma