Table 4.
Association between BMI change and SCC UADT cancer, stratified by risk factors.
| <−5% (weight loss) |
−5% to <+5% | 5% to <25% | ≥25% | P trend** | |
|---|---|---|---|---|---|
| BMI at 21 (kg/m2) | |||||
| Tertile 1 (<20.96 ) | |||||
| case/controls | 8/1 | 29/36 | 59/137 | 64/169 | |
| Adj OR (95% CI)1 | 9.36 (0.92, 95.0) | 1.00 | 0.71 (0.34, 1.48) | 0.52 (0.24, 1.11) | 0.084 |
| Tertile 2 (20.96 to <23.56) | |||||
| case/controls | 12/8 | 37/51 | 72/174 | 42/113 | |
| Adj OR (95% CI) 1 | 1.50 (0.46, 4.91) | 1.00 | 0.48 (0.26, 0.88) | 0.42 (0.22, 0.81) | 0.017 |
| Tertile 3 (≥23.56) | |||||
| case/controls | 31/30 | 41/52 | 88/159 | 30/93 | |
| Adj OR (95% CI) 1 | 0.96 (0.44, 2.07) | 1.00 | 0.72 (0.41, 1.26) | 0.44 (0.22, 0.87) | 0.014 |
| Tobacco Smoking Status | |||||
| Never | |||||
| case/controls | 14/12 | 26/70 | 78/224 | 40/176 | |
| Adj OR (95% CI)2 | 2.37 (0.88, 6.39) | 1.00 | 0.99 (0.57, 1.74) | 0.69 (0.37, 1.27) | 0.146 |
| Former | |||||
| case/controls | 30/15 | 51/42 | 107/168 | 77/132 | |
| Adj OR (95% CI) 2 | 1.59 (0.67, 3.80) | 1.00 | 0.53 (0.30, 0.93) | 0.41 (0.23, 0.76) | 0.006 |
| Current | |||||
| case/controls | 7/12 | 30/27 | 34/78 | 19/67 | |
| Adj OR (95% CI) 2 | 0.39 (0.11, 1.38) | 1.00 | 0.39 (0.17, 0.85) | 0.23 (0.09, 0.58) | 0.004 |
| Alcohol Drinking Status | |||||
| Never | |||||
| case/controls | 6/14 | 18/33 | 43/100 | 32/109 | |
| Adj OR (95% CI)3 | 0.51 (0.14, 1.85) | 1.00 | 0.67 (0.32, 1.41) | 0.59 (0.27, 1.28) | 0.187 |
| Former drinker | |||||
| case/controls | 28/10 | 50/26 | 113/83 | 75/78 | |
| Adj OR (95% CI) 3 | 1.35 (0.53, 3.42) | 1.00 | 0.86 (0.47, 1.58) | 0.62 (0.33, 1.17) | 0.136 |
| Current | |||||
| case/controls | 16/15 | 39/79 | 63/286 | 28/187 | |
| Adj OR (95% CI) 3 | 1.98 (0.83, 4.72) | 1.00 | 0.44 (0.26, 0.74) | 0.26 (0.14, 0.49) | <0.001 |
|
Tobacco Smoking Pack- years |
|||||
| <20 | |||||
| case/controls | 12/15 | 19/48 | 51/163 | 39/120 | |
| Adj OR (95% CI)2 | 1.52 (0.52, 4.42) | 1.00 | 0.62 (0.31, 1.23) | 0.53 (0.25, 1.12) | 0.157 |
| ≥20 | |||||
| case/controls | 25/12 | 62/21 | 90/83 | 57/79 | |
| Adj OR (95% CI)2 | 0.57 (0.22, 1.48) | 1.00 | 0.36 (0.18, 0.71) | 0.22 (0.10, 0.45) | <0.001 |
|
Time Since Quitting Tobacco Smoking |
|||||
| ≤ 3 years | |||||
| case/controls | 24/7 | 40/8 | 63/24 | 39/17 | |
| Adj OR (95% CI)2 | 0.66 (0.18, 2.47) | 1.00 | 0.56 (0.19, 1.59) | 0.39 (0.12, 1.23) | 0.133 |
| >3 years | |||||
| case/controls | 6/8 | 11/34 | 44/144 | 38/115 | |
| Adj OR (95% CI)2 | 2.60 (0.56, 12.0) | 1.00 | 0.86 (0.36, 2.03) | 0.74 (0.30, 1.79) | 0.394 |
1
Adjusted for age, gender, ethnicity, tobacco smoking status, pack-years, drinking status, drinking years, education, calories.
2
Adjusted for age, gender, ethnicity, drinking status, drinking years, education, calories.
3
Adjusted for age, gender, ethnicity, tobacco smoking status, pack-years, education, calories.
*
Tertile 1 <20.96, Tertile 2 from 20.96 to <23.56, Tertile 3 ≥23.56
**
Negative BMI change (weight loss) excluded.
Adj: Adjusted, BMI: Body Mass Index, SCC: Squamous Cell Carcinoma