Table 1.
Clinical, PiB and FDG regions-of-interest measures by family history group
| NH | PH | MH | ||||
|---|---|---|---|---|---|---|
| N | 16 | 12 | 19 | |||
| Age (years) | 67(7) | 65(7) | 62(7) | |||
| Gender (F/M) | 5/11 | 6/6 | 12/7 | |||
| Education (years) | 10(4) | 11(5) | 11(5) | |||
| ApoE ε4 (+/−) | 5/11 | 6/6 | 9/10 | |||
| MMSE | 29(1) | 29(1) | 29(1) | |||
| PiB SUVR | Left | Right | Left | Right | Left | Right |
| Anterior Putamen | 1.39(.18) | 1.44(.16) | 1.25(.18) | 1.43(.45) | 1.62(.44) | 1.67(.32)*# |
| Hippocampus | 1.25(.17) | 1.25(.21) | 1.26(.19) | 1.20(.14) | 1.38(.21) | 1.35(.22) |
| Inferior Parietal lobe | 1.35(.19) | 1.19(.15) | 1.41(.22) | 1.25(.13) | 1.57(.34)*# | 1.41(.35)* |
| Lateral temporal lobe | 1.33(.16) | 1.27(.20) | 1.35(.20) | 1.33(.15) | 1.51(.31)*# | 1.50(.27)*# |
| Medial frontal gyrus | 1.24(.15) | 1.08(.15) | 1.31(.18) | 1.15(.14) | 1.53(.40)*# | 1.33(.36)* |
| Occipital cortex | 1.32(.18) | 1.35(.16) | 1.32(.16) | 1.33(.17) | 1.42(.18) | 1.45(.19)# |
| Posterior cingulate | 1.28(.14) | 1.34(.16) | 1.42(.22) | 1.43(.20) | 1.59(.38)*# | 1.49(.42)* |
| Prefrontal cortex | 1.23(.18) | 1.19(.17) | 1.29(.18) | 1.30(.12) | 1.48(.41)*# | 1.47(.38)*# |
| Thalamus | 1.41(.42) | 1.44(.18) | 1.42(.36) | 1.39(.24) | 1.51(.31) | 1.55(.25)*# |
| FDG SUVR | ||||||
| Anterior Putamen | 1.27(.13) | 1.25(.11) | 1.30(.18) | 1.36(.19) | 1.23(.16) | 1.25(.17)# |
| Hippocampus | 0.86(.10) | 0.87(.91) | 0.89(.11) | 0.91(.11) | 0.79(.07)*# | 0.83(.09)# |
| Inferior Parietal lobe | 1.22(.12) | 1.18(.13) | 1.24(.18) | 1.20(.19) | 1.16(.12)*# | 1.12(.13)*# |
| Lateral temporal lobe | 1.08(.11) | 1.09(.09) | 1.11(.15) | 1.12(.13) | 1.07(.10) | 1.02(.09)*# |
| Medial frontal gyrus | 1.27(.12) | 1.16(.12) | 1.30(.21) | 1.18(.23) | 1.22(.13) | 1.08(.13)# |
| Occipital cortex | 1.23(.16) | 1.24(.15) | 1.30(.21) | 1.31(.20) | 1.22(.17) | 1.23(.17) |
| Posterior cingulate | 1.41(.18) | 1.38(.19) | 1.42(.20) | 1.39(.21) | 1.29(.15)*# | 1.24(.15)*# |
| Prefrontal cortex | 1.10(.11) | 1.18(.12) | 1.13(.19) | 1.22(.19) | 1.03(.12)# | 1.11(.11)*# |
| Thalamus | 1.21(.13) | 1.18(.11) | 1.25(.21) | 1.26(.19) | 1.18(.14) | 1.16(.15) |
| ADPiB-mask | 1.22(.15) | 1.35(.21) | 1.51(.35)*# | |||
| ADFDG-mask | 1.27(.15) | 1.31(.21) | 1.18(.16)*# | |||
Values are mean (SD) PiB and FDG standardized uptake volume ratios (SUVR, unitless) adjusted for age, gender and education.
*
MH ≠ NH,
#
MH ≠ PH,
+PH ≠ NH, P<0.05.