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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Cancer. 2012 Apr 19;118(21):5432–5440. doi: 10.1002/cncr.27536

Table 1.

Data including references for the excess hazard ratio (hrexcess) dependency used in the risk modeling.

Studied endpoint Dose-response
function, hrexcess/Gy		 Type of study for
dose-response		 Age at exposure
dependence, e 		Male:Female
risk ratio		 References
Breast cancer hrexcess = 0.149·Dmean Nested case-control
study of female HL
survivors
diagnosed at age ≤
30 years		 No trend in risk for
childhood cancer
patients ages < 21
years		 - Dose-response:
Travis et al. (2003)
Age and sex:
Kenney et al. (2004)
Lung cancer hrexcess = 0.194·Dmean Nested case-control
study of HL
survivors		 Too few cases from
childhood cancer
survivors to see
effect		 1:1.7* Dose-response:
Travis et al. (2005)
Age and sex:
Swerdlow et al. (2000)
Bassal et al. (2006)
Thyroid cancer hrexcess = β1D·exp(−β4D2) Nested case-control
study of childhood
cancer survivors		 Significant linear
trend:

β1 = 2·81−0·15·e
B4 = 0·00164		 1:1.7 Dose-response:
Bhatti et al. (2010)
Age and sex:
Bhatti et al. (2010)
Stomach cancer hrexcess = 0.84·Dmean Cohort/Nested
case-control study
of survivors of
testicular cancer or
HL		 Patients < 20 years
at higher risk than
adults but no trend
in childhood data		 1:3.7* Dose-response:
Belt-Dusebout et al. (2009)
Age and sex:
Belt-Dusebout et al. (2009)
Bassal et al. (2006)
Cardiac complications
   - Heart Failure

   - Myocardial infarction 		hrexcess = 0.117·Dmean

hrexcess = 0.096·Dmean 		Cohort study of
childhood cancer
survivors with
siblings as
comparison		 Almost significant
linear trends of
higher risk for
younger age
1:1.4

1:0.6
Dose-response:
Mulrooney et al. (2009)
Age and sex:
Mulrooney et al. (2009)
*

Based on adult data

HL - Hodgkin Lymphoma