Figure 4.
High K+ aCSF stimulated OXT (F(6,5) = 11.76, p < 0.0001) and AVP (F(6,5) = 6.90, p = 0.002) release (A). Black bar represents the time in which high K+ was in aCSF. Systemic injection of hypertonic saline (black arrow) caused a transient increase in OXT (F(12,5) = 7.33, p < 0.0001) while causing a delayed and long lasting increase in AVP (B) (F(12,5) = 8.65, p < 0.0001). RM ANOVA and a post-hoc Tukey test were performed to compare basal levels against post drug levels. All in vivo microdialysis data are expressed as percent of baseline ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared to basal levels in the PVN.
