Fig. 3.

Patterns of FM 50-kHz USV responses to amphetamine two-injection protocol of sensitization. a Averaged response profiles of negative responders (negR); b averaged response profiles of low responders (LR); c averaged response profiles of high responders (HR). Please note that the averaged 2-min interval response profiles are shown only for illustration and the ANOVA results shown refer to 10-min time “blocks”. Three-way ANOVA—group effect: F _{2, 19} = 7.19, p = 0.005; day effect: F _{1, 19} = 4.16, p = 0.055; post-drug session time effect: F _{1, 19} = 15.23, p = 0.001; day × group interaction effect: F _{2, 19} = 14.22, p < 0.001; group × post-drug session time interaction effect: F _{2, 19} = 4.94, p = 0.019; day × post-drug session time interaction effect: F _{2, 19} = 9.04, p = 0.007; day × post-drug session time × group interaction effect: F _{2, 19} = 12.31, p < 0.001. *p < 0.05, **p < 0.01 vs. the corresponding 10-min block value for day 1; the Tukey test