Fig. 4.

Effect of repetitive amphetamine treatment on FM 50-kHz USV response profiles in various rat subsets (negR negative responders, LR low responders, HR high responders). The upper panels are for illustration purpose only; hence, error bars are not shown. The ANOVA results given below refer to the data shown in the lower panels. Three-way ANOVA—group effect: F _{2, 19} = 14.88, p < 0.001; day effect: F _{3, 57} = 8.89, p < 0.001; post-drug session time effect: F _{1, 19} = 0.35, p = 0.56; day × group interaction effect: F _{6, 57} = 6.24, p < 0.001; group × post-drug session time effect: F _{2, 19} = 0.90, p = 0.42; day × post-drug session time interaction effect: F _{3, 57} = 11.90, p < 0.001; day × group × post-drug session time interaction effect: F _{6, 57} = 3.59, p = 0.004. *p < 0.05, ***p < 0.001 vs. the respective day 1 10-min block value; Δp < 0.05, ΔΔΔp < 0.001 vs. the respective day 7 10-min block value; •p < 0.05, •••p < 0.001 vs. the corresponding HR group value; the Tukey test