Table 2.
Phenotypic comparisons between Ikbkg and Sharpin mutations in mice
| Ikbkg allelic mutations (Ikbkgtm1Mka and Ikbkgtm1Mpa) | Sharpin mutation (Sharpincpdm) | |
|---|---|---|
| Genetic locus | Chr. X | Chr. 15 |
| Embryonic lethality | Yes in males No in heterozygous females | No |
| Growth retardation | Yes | Yes |
| Onset of disease | 3–4 days after birth | 3–4 weeks after birth |
| Spleen | Decreased in size, no marginal zone | Enlarged in size, no marginal zone |
| Skin | Alopecia, inflammation with granulocytic infiltration, apoptotic keratinocytes | Alopecia, inflammation with granulocytic infiltration, apoptotic keratinocytes |
| Epidermis thickness | Increased | Increased |
| Dominant cytokines in skin | IL1α, IL1β, TNF, IFNG, TGFB1/2 | IL4, IL5, IL13 |
| Sensitivity to TNF-induced apoptosis | Increased | Increased |
| Melanin deposits | Yes | No |