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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Behav Brain Res. 2012 May 23;233(2):280–287. doi: 10.1016/j.bbr.2012.05.022

Figure 1.

Figure 1

Age and strain effects on nicotine preference. Female and male early adolescent (pnd 24–35) (a), middle adolescent (pnd 36–47) (b), late adolescent (pnd 48–59) (c), and adult (pnd 60+) (d) C3H/Ibg and C57BL/6J mice were examined for nicotine preference (percentage of total daily fluid consumed from the nicotine bottle) in a 2 bottle choice test. Analysis indicated that there was a main affect of age (p = 1.2 × 10−5) but not strain or sex for nicotine preference. Within strain results showed that early (p = 0.007) and middle adolescent (p = 1.1 × 10−5) C3H/Ibg mice had reduced preference for nicotine relative to adults (e). In contrast, early adolescent C57BL/6J mice exhibited reduced preference for nicotine relative to middle adolescent (p = 0.018) and adult (p = 0.015) animals (f). Data represent mean ± SEM.