Figure 3.
Age and strain effects on the number of zero maze open quadrant entries. Drug naïve early adolescent (a), middle adolescent (b), late adolescent (c), and adult (d) inbred animals were tested on a zero maze for baseline differences in the number of open quadrant entries. Analysis identified a significant effect of age (p = 9.6 × 10−16), strain (p = 1.3 × 10−17), and an age x strain interaction (p = 2.9 × 10−5) (the data were collapsed on sex due to no effect) with middle and late adolescents exhibiting a greater number of open arm entries than either early adolescent or adult animals. Data represent mean ± SEM.
