. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: Neurotoxicology. 2012 Mar 7;36:106–111. doi: 10.1016/j.neuro.2012.02.016

Table 2. Neurotransmitter levels in the PVN of PM2.5 exposed BN and JCR/LA rats.

Neurotransmitter levels in the PVN were measured by HPLC-EC after 1 day and 3 or 4 day PM_2.5 exposure in BN and JCR rats. There were no significant changes in DA levels, but 5-HIAA, a metabolite of serotonin increased significantly after repeated PM_2.5 exposures in both BN and JCR/LA rats.

BN rats	Neurotransmitters	1 day exposure		3 day exposure
	Neurotransmitters	Air	PM_2.5	Air	PM_2.5
	Dopamine (pg/µg)	1.8±1.2	2.0±0.7	0.6±0.1	0.6±0.1
	5-HIAA (pg/µg)	2.6±0.4	7.6±2.5*	6.8±0.9*	7.4±0.2*

JCR/LA rats	Neurotransmitters	4 day exposure
	Neurotransmitters	Air	PM_2.5
	Dopamine (pg/µg)	0.5±0.1	0.7±0.1
	5-HIAA (pg/µg)	7.5±1.1	12±1.6*