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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Transfusion. 2012 Apr 9;52(12):2706–2716. doi: 10.1111/j.1537-2995.2012.03636.x

Figure 3.

Figure 3

Schematic representation of some of the interactions occurring during HSPC homing. Conditioning for transplantation induces a proteolytic microenvironment (e.g., release of matrix metalloproteinase (MMP)-9) that activates the complement cascade and leads to the generation of the MAC. In addition, the concentrations of the bioactive lipids S1P and ceramide-1 phosphate (C1P) increase in the bone marrow after conditioning for transplantation. Both S1P and C1P are potent chemoattractants for HSPC. Moreover, agents priming responses to SDF-1 (e.g., C3a, which acts through its receptor C3aR) enhance the incorporation of CXCR4 into the lipid rafts of the cell membrane of HSPC. All these interactions lead to chemoattraction and lodgement of HSPC in the bone marrow niche.