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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Mol Microbiol. 2012 Jul 5;85(3):557–573. doi: 10.1111/j.1365-2958.2012.08127.x

Figure 7. A model for Brg1p function in C. albicans hyphal induction.

Figure 7

BRG1 is an important component of hyphal induction in C. albicans. A. Under yeast conditions, BRG1 is repressed in an Nrg1p-mediated fashion. During hyphal induction, BRG1 expression is rapidly and substantially increased. This leads to Brg1p-dependent induction of an antisense NRG1 transcript (wavy line) and subsequent destruction of the NRG1 sense transcript (thin arrow) by an, as yet unknown, argonaute-independent mechanism (dashed lines). B. Brg1p acts in a feedback mechanism with NRG1 to regulate hypha-specific gene (HSGs) expression. BRG1 expression is upregulated by appropriate environmental stimuli, resulting in decreased NRG1 transcript levels and stimulation of hypha-specific gene expression. As BRG1 levels fall after the initial phase of induction, NRG1 levels are able to rise and the system is reset.