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. Author manuscript; available in PMC: 2013 Sep 6.
Published in final edited form as: Neuroscience. 2012 Jun 1;219:92–110. doi: 10.1016/j.neuroscience.2012.05.059

Figure 9. Cumulative PRCs make intrinsic and synaptic background contributions to shifts in spike timing distinguishable.

Figure 9

A. Cumulative PRCs (cPRCs) for somatic stimulation of GPbase attenuate gradually over 10 spike cycles (A1) without a notable change in shape or y-translation (A2). Note, A2 plots the same single cycle cPRCs (F1, F2, etc.) from A1 on the same x-axis to allow direct comparison of shape. Changes in shape or y-translations of cPRCs reflect the contributions of intrinsic mechanisms to spike timing, whereas attenuation of cPRCs reflect the effect of synaptic backgrounds forcing the spiking trajectory back to the control pattern. B. Cumulative PRCs for distal dendritic stimulation of GPbase show significant positive and negative regions for each spike cycle after the stimulated cycle. These dendritic cPRCs attenuate over 6 to 7 spike cycles, notably faster than for somatic stimuli (B1), and show a pronounced negative y-translation between the F1 and F2 cPRCs reflecting the delaying effect of evoked dendritic SK on spike timing (B2). C. Like cPRCs for somatic stimulation of GPbase, cPRCs for distal dendritic stimulation of the GPNDSK model show a single positive peak and attenuate over 10 spike cycles (C1) without a notable change in shape or y-translation (C2).