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MTHFR C677T genotype frequency and allele frequency between the two groups.
| Genotypes and alleles | Controls (n=370) n (%) |
Cases (n=370) n (%) |
χ2 | P-value |
|---|---|---|---|---|
| C | 456 (61.6) | 415 (56.1) | 4.690 | 0.030 |
| T | 284 (38.4) | 325 (43.9) | ||
| CC | 139 (37.6) | 124 (33.5) | 6.327 | 0.042 |
| CT | 178 (48.1) | 167 (45.1) | ||
| TT | 53 (14.3) | 79 (21.4) |
TT genotype and T allele were significantly higher in frequency in the CRC group than in the control group. MTHFR, methylenetetrahydrofolate reductase; CRC, colorectal cancer.
