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. 2012 May 23;21(8):670–675. doi: 10.1136/bmjqs-2011-000643

Table 2.

Adverse drug events (ADEs)

Triggers (n) Unique episodes (n) ADEs (n) Proportion triggers that were ADEs (95% CI) Stage Effect on patient
INR >5 85 48 46 0.96 (0.90 to 1)

  • 0 Prescribing

  • 0 Dispensing

  • 0 Self-administration

  • 46 Monitoring

  • 0 None

  • 35 Minimal

  • 8 Mild

  • 3 Moderate

  • 0 Severe

  • 0 NA
BUN >60 mg/dl 618 103 12 0.12 (0.06 to 0.18)

  • 0 Prescribing

  • 0 Dispensing

  • 12 Self-administration

  • 0 Monitoring

  • 0 None

  • 7 Minimal

  • 4 Mild

  • 0 Moderate

  • 1 Severe

  • 0 NA
ALT >84 lU/l 644 205 19 0.09 (0.07 to 0.11)

  • 0 Prescribing

  • 0 Dispensing

  • 16 Self-administration

  • 2 Monitoring

  • 1 NA

  • 0 None

  • 16 Minimal

  • 0 Mild

  • 1 Moderate

  • 1 Severe

  • 1 NA
Creatinine >2.5 mg/dl 123 862 10 0.08 (0.06 to 0.10)

  • 0 Prescribing

  • 0 Dispensing

  • 10 Self Administration

  • 0 Monitoring

  • 0 None

  • 4 Minimal

  • 5 Mild

  • 0 Moderate

  • 1 Severe

  • 0 NA
AST >80 IU/I 453 143 4 0.03 (0.00 to 0.06)

  • 0 Prescribing

  • 0 Dispensing

  • 3 Self-administration

  • 1 Monitoring

  • 0 None

  • 3 Minimal

  • 0 Mild

  • 1 Moderate

  • 0 Severe

  • 0 NA
Total 1342 622 91 0.15 (0.12 to 0.18)

  • 0 Prescribing

  • 0 Dispensing

  • 41 Self-administration

  • 49 Monitoring

  • 1 NA

  • 0 None

  • 65 Minimal

  • 17 Mild

  • 5 Moderate

  • 3 Severe

  • 1 NA

ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; INR, international normalised ratio.