Figure 3.

The effects of corticosteroids on IFN-γ and LPS-induced IP-10. AM were treated with dexamethasone for 1 h before stimulation with IFN-γ (100 ng·mL⁻¹) (NS, n= 3; S, n= 8, COPD, n= 7) for 16 h (A-C) or LPS (1 µg·mL⁻¹) (NS, n= 8; S, n= 8; COPD, n= 7) for 24 h (D–F). IP-10 levels in culture supernatants were measured by elisa. Data presented as median absolute levels of IP-10 (pg·mL⁻¹) with whiskers showing total range. Intragroup analysis used the Freidmen test, with results for all conditions being non-significant (ns). Due to low sample numbers, statistical analysis could not be carried out on data depicted in (A).