Table 1.
Voltage-dependence and kinetics of Nav1.2, Nav1.8 and chimeras
| α-Subunits | Chimeras | ||||||
|---|---|---|---|---|---|---|---|
| Parameters | Nav1.2 | Nav1.8 | 8822 | 8288 | 2/8822 | 8/2288 | 8882 |
| Vrev (mV) | 42.0 ± 3.6 (7) | 41.6 ± 1.2 (18) | 39.9 ± 1.0 (16) | 45.6 ± 3.7 (13) | 44.7 ± 1.5 (32) | 47.4 ± 2.9 (14) | 45.8 ± 1.9 (20) |
| V0.5act (mV) | −33.0 ± 0.7 (7) | −3.0 ± 0.8 (18) | −17.8 ± 1.9 (16) | −12.5 ± 2.5 (13) | 4.9 ± 1.2 (32) | −17.5 ± 1.3 (14) | −2.4 ± 0.8 (20) |
| τact (ms) | 0.7 ± 0.04 (12) | 1.4 ± 0.04 (15) | 1.2 ± 0.1 (16) | 1.0 ± 0.03 (10) | 1.2 ± 0.03 (18) | 0.8 ± 0.1 (12) | 2.8 ± 0.04 (19) |
| V0.5inact (mV) | −63.0 ± 0.9 (20) | −38.4 ± 1.0 (27) | −39.1 ± 1.8 (15) | −39.0 ± 0.7 (11) | −37.5 ± 0.6 (16) | −47.5 ± 0.5 (10) | −35.0 ± 0.8 (16) |
| τinact (ms) | 2.5 ± 0.03 (7) | 6.6 ± 0.03 (15) | 6.7 ± 0.2 (16) | 5.7 ± 0.04 (10) | 15.3 ± 0.2 (10) | 3.4 ± 0.3 (11) | 14.1 ± 0.2 (5) |
Values are presented as mean ± SEM. The number of oocytes is given in parentheses. The amplitude of Na+ currents recorded for chimera 8822 was insufficient for detailed analysis and not included.