Figure 4.

Obesity impairs neutrophil chemotaxis. Chemotaxis of density centrifugation-isolated mature bone marrow neutrophils from genetically obese (db/db) (A) and diet-induced obese (B) mice was compared with lean control mice using a modified Boyden chamber with KC (25 ng/ml). Membrane counts were expressed as percentage of lean control neutrophil migration to KC for each experiment. Four separate experiments were performed on db/db and diet-induced obese mouse isolated neutrophils and respective control mice. *P < 0.01.