TABLE 3.
TOP-ENRICHED PATHWAYS IN CULTURED LYMPHOCYTES FROM NONSENSE-MEDIATED DECAY–POSITIVE BMPR2 MUTATION CARRIERS WITH PULMONARY ARTERIAL HYPERTENSION
| Pathway | Genes (n) | Nes | Nom P Value |
| Apoptotic nuclear changes | 19 | 1.671 | 0.010 |
| Cell division | 17 | 1.600 | 0.019 |
| Cytokinesis | 15 | 1.591 | 0.015 |
| Establishment of organelle localization | 16 | 1.576 | 0.034 |
| Regulation of G-protein–coupled receptor protein signaling pathway | 22 | 1.569 | 0.044 |
| M phase of mitotic cell cycle | 83 | 1.569 | 0.041 |
| Nuclear organization and biogenesis | 30 | 1.565 | 0.019 |
| Chromatin remodeling | 23 | 1.562 | 0.032 |
| Mitosis | 81 | 1.548 | 0.051 |
| Mitotic cell cycle | 147 | 1.548 | 0.047 |
| Cell cycle process | 188 | 1.539 | 0.053 |
| Organelle localization | 23 | 1.535 | 0.051 |
| Cell cycle phase | 167 | 1.525 | 0.059 |
| M phase | 112 | 1.516 | 0.058 |
| Interphase | 66 | 1.498 | 0.064 |
Definition of abbreviations: Nes, normalized error squared; Nom, nominal.