Table 1.

Summary of the input parameters and their estimates derived from 50 simulated data sets using equation 6

Simulation*	Emax	pKa	logε	logχ1	logχ2	logχ3	logχ4	logχ5	logn	basal
1. Input	1.50	9.70	3.00	−2.91	−2.43	−1.95	−1.48	−1.00	−0.15	0.90
1. Estimate	1.50 ± 0.12	9.67 ± 0.11	3.08 ± 0.25	−2.99 ± 0.23	−2.50 ± 0.21	−2.03 ± 0.19	−1.54 ± 0.18	−1.06 ± 0.15	−0.17 ± 0.05	0.89 ± 0.06
2. Input	1.50	9.70	2.00	−2.29	−1.89	−1.49	−1.10	−0.70	0.00	0.90
2. Estimate	1.50 ± 0.11	9.70 ± 0.12	2.01 ± 0.23	−2.30 ± 0.27	−1.90 ± 0.22	−1.50 ± 0.19	−1.10 ± 0.16	−0.71 ± 0.11	0.00 ± 0.06	0.92 ± 0.06
3. Input	1.50	9.70	1.48	−1.60	−1.30	−1.00	−0.70	−0.40	0.30	0.90
3. Estimate	1.49 ± 0.09	9.75 ± 0.12	1.37 ± 0.26	−1.48 ± 0.28	−1.21 ± 0.23	−0.93 ± 0.18	−0.64 ± 0.14	−0.37 ± 0.09	0.35 ± 0.10	0.90 ± 0.05
4. Input	1.50	9.70	1.48	−1.42	−1.02	−0.62	−0.22	0.18	0.30	0.90
4. Estimate	1.47 ± 0.08	9.72 ± 0.13	1.42 ± 0.26	−1.35 ± 0.24	−0.97 ± 0.17	−0.60 ± 0.12	−0.21 ± 0.05	0.17 ± 0.05	0.32 ± 0.10	0.90 ± 0.05
5. Input	1.50	9.70	1.48	−1.60	−1.30	−1.00	−0.70	−0.40	0.30	0.90
5. Estimate	1.49 ± 0.12	9.81 ± 0.33	1.25 ± 0.67	−1.36 ± 0.72	−1.10 ± 0.57	−0.85 ± 0.45	−0.62 ± 0.35	−0.35 ± 0.21	0.52 ± 0.49	0.89 ± 0.06
6. Input	1.50	9.70	1.48	−1.60	−1.30	−1.00	−0.70	−0.40	0.30	0.90
6.Estimate	1.47 ± 0.11	9.70 ± 0.21	1.48 ± 0.41	−1.61 ± 0.44	−1.32 ± 0.37	−1.01 ± 0.28	−0.71 ± 0.22	−0.42 ± 0.15	0.34 ± 0.18	0.89 ± 0.05

^*Simulations 1–4 were performed with a within-occasion standard error of 3%, simulations 5 and 6 with a standard error of 6%. Simulation 6 was performed with duplicate determinations.

Parameter estimates are presented as mean ± SD.