Table 8.
Summary of the parameters of the concentration-response curves to CCL17 at different mean CCR4 expression levels
| CCR4 expression | pEC50 | Emax | basal | n |
|---|---|---|---|---|
| Low | 9.01 ± 0.22 | 0.50 ± 0.03 | 0.98 ± 0.01 | 0.74 (0.52, 1.06) |
| Low-mid | 9.35 ± 0.21 | 0.78 ± 0.03 | 0.99 ± 0.02 | 1.12 (0.71, 1.79) |
| Mid | 9.70 ± 0.11 | 0.99 ± 0.04 | 1.01 ± 0.02 | 1.36 (0.62, 2.97) |
| High-mid | 9.85 ± 0.10 | 1.19 ± 0.05 | 1.06 ± 0.01 | 1.58 (1.38, 1.81) |
| High | 10.04 ± 0.10 | 1.44 ± 0.08 | 1.10 ± 0.03 | 1.38 (1.19, 1.59) |
Values are the mean ± SEM of four determinations in separate donors except for n, which is presented as geometric mean with 95% confidence interval in parentheses.