Figure 2.

Effect of curcumin on systemic exposure to sulphasalazine following oral administration in wild-type and Bcrp(–/–) mice. Female wild-type (panel A) and Bcrp(–/–) mice (panel B) were given oral sulphasalazine (10 mg·kg⁻¹) alone, or with a pretreatment of curcumin at 150, 300 and 400 mg kg⁻¹, 1 h before the sulphasalazine dose. Plasma concentrations of sulphasalazine were determined at the times shown. Data shown are mean (±SEM) values of the plasma concentrations (n= 5 or 6). In (C) and (D) the AUC_0–8 corresponding to the data in (A) and (B) respectively, was calculated by the trapezoidal method. *P < 0.05, significantly different from control; one-way anova with Dunnett's post hoc multiple comparison test.