Figure 4.
Effect of curcumin on Cmax and AUC of sulphasalazine given orally at a microdose and at a therapeutic dose. Cmax and AUC at a microdose (A) and a therapeutic dose (B) were calculated based on data shown in Figure 3. Values are expressed as box (lower and upper quartiles) and whisker (the furthest data points still within a distance of 1.5 interquartile ranges from the lower and upper quartiles) plots with medians shown as the horizontal line. *P < 0.05, significantly different from control; paired t-test.