Table 2.
Schild analyses of contractile responses to endothelins in the presence of ETA antagonists
| Antagonist | Agonist | Slope | pA2 or pKBa |
|---|---|---|---|
| BQ123 | ET-1 | 0.69 ± 0.08 | 7.6 ± 0.4 |
| BQ123 | ET-2 | 1.0 ± 0 | 5.6 ± 0.4a |
| BQ123 | ET-3 | 0.86 ± 0.35 | 8.3 ± 0.4 |
| PD156707 | ET-1 | 0.71 ± 0.15 | 8.5 ± 0.3 |
| PD156707 | ET-2 | 1.55 ± 0.6 | 7.9 ± 0.3 |
| PD156707 | ET-3 | 1.4 ± 0.35 | 8.8 ± 0.2 |
| FITC-BQ123 | ET-1 | 0.65 ± 0.13 | 8.3 ± 0.7 |
| Cy5.5-PD156707 | ET-1 | 1.09 ± 0.15 | 8.2 ± 0.5 |
| (PD156707)2 | ET-1 | 1.07 ± 0.35 | 7.7 ± 0.5 |
Data shown as mean ± SEM (n= 4–8).
a
Denotes calculation of a pKB value for BQ123 versus ET-2.