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Effects of the R(−) and S(+) enantiomers of NαMe-αClMeHA on specific [125I]IPX binding (A) and forskolin-induced cAMP accumulation (B) in CHO(rH3(445)R) and CHO(rH3(413)R) cells expressing 500 fmol·mg−1 protein of receptor. Each point represents the mean ± SEM of values from two to three different experiments with three to five determinations each. *P < 0.05, **P < 0.01, significantly different from S(+) NαMe-αClMeHA.
