. 2012 Jul;166(6):1860–1871. doi: 10.1111/j.1476-5381.2012.01913.x

Table 2.

Compared properties of R(−) and S(+) sopromidine at the recombinant rH₃₍₄₄₅₎ and rH₃₍₄₁₃₎ receptor isoforms and at the rat H₃ autoreceptor

	R(−) sopromidine			S(+) sopromidine
Condition	rH₃₍₄₄₅₎ receptor	rH₃₍₄₁₃₎ receptor	H₃ autoreceptor^a	rH₃₍₄₄₅₎ receptor	rH₃₍₄₁₃₎ receptor	H₃ autoreceptor^a
Alone	Full agonist (EC₅₀= 79 ± 34 nM)	Partial agonist (EC₅₀= 91 ± 78 nM)	nd	Inverse agonist (EC₅₀= 180 ± 90 nM)	Inverse agonist (EC₅₀= 340 ± 92 nM)	nd
With histamine	No effect (K_i > 100 µM)	Antagonist (K_i= 63 ± 40 nM)	Antagonist (K_i= 56 ± 22 nM)	Antagonist (K_i= 250 ± 120 nM)	Antagonist (K_i= 220 ± 100 nM)	Antagonist (K_i= 45 ± 11 nM)

Values from Arrang et al. (1985a). The values at the two isoforms are derived from data shown in Figure 4.

nd, not determined.