Table 1.
Effects of AICAR treatment on serum biochemistry in rats with kidney I/R injury
| Variable | Sham (n= 17) | RIR (n= 19) | RIR + AICAR50 (n= 8) | RIR + AICAR160 (n= 9) | RIR + AICAR500 (n= 8) | anova P-value |
|---|---|---|---|---|---|---|
| s-ALAT (U·L−1) | 39.3 ± 2.8 | 77.7 ± 4.2* | 67 ± 7.1* | 59 ± 4.0* | 62 ± 6.2* | 0.2413 |
| s-AFOS (U·L−1) | 257.9 ± 15.3 | 324.6 ± 17.7 | 293 ± 17.1 | 292 ± 23.1 | 321 ± 37.8 | 0.2840 |
| s-ASAT (U·L−1) | 120.4 ± 5.9 | 612.5 ± 42.1* | 648 ± 96.3* | 505 ± 52.1* | 374 ± 49.2*# | <0.0001 |
| s-GGT (U·L−1) | 0.0 ± 0 | 27.3 ± 2.6 | 26.1 ± 6.0 | 19.2 ± 2.8 | 13.2 ± 2.5 | <0.0001 |
| s-GLDH (U·L−1) | 10.0 ± 0.8 | 198.8 ± 19.8* | 195 ± 28.0* | 201 ± 24.4* | 129 ± 31.7* | <0.0001 |
| s-Protein(g·L−1) | 52.1 ± 0.8 | 52.5 ± 0.8 | 53.6 ± 1.3 | 52.6 ± 1.8 | 53.3 ± 1.2 | 0.4843 |
| s-Albumin (g·L−1) | 27.9 ± 0.4 | 27.6 ± 0.5 | 28.4 ± 0.7 | 27.7 ± 0.8 | 28.0 ± 0.5 | 0.4838 |
| s-K (mmol·L−1) | 4.7 ± 0.1 | 6.9 ± 0.3* | 6.4 ± 0.3* | 6.1 ± 0.2* | 5.6 ± 0.3# | <0.0001 |
| s-Na (mmol·L−1) | 143.3 ± 1.7 | 142.6 ± 2.2 | 149 ± 1.0 | 145 ± 1.9 | 150 ± 0.9 | 0.0267 |
| s-Cl (mmol·L−1) | 99.6 ± 0.9 | 91.5 ± 1.2* | 98 ± 2.7# | 95 ± 1.9 | 100 ± 2.0# | 0.1513 |
| s-Calsium (mmol·L−1) | 2.4 ± 0.0 | 2.4 ± 0.0 | 2.55 ± 0.1 | 2.47 ± 0.1 | 2.50 ± 0.0 | 0.0002 |
| s-Pi (mmol·L−1) | 2.9 ± 0.1 | 4.7 ± 0.3* | 4.3 ± 0.3* | 4.2 ± 0.3* | 3.7 ± 0.3 | <0.0001 |
| s-Chol (mmol·L−1) | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.50 ± 0.1 | 1.45 ± 0.1 | 1.67 ± 0.1 | 0.8392 |
| s-Trigly (mmol·L−1) | 0.8 ± 0.0 | 0.9 ± 0.1 | 0.89 ± 0.1 | 0.76 ± 0.1 | 0.71 ± 0.1 | 0.0406 |
Sham denotes sham-operated rats; RIR, rats with renal I/R injury; RIR+AICAR50, rats with I/R injury treated with AICAR at the dose 50 mg·kg−1 i.v.; RIR+AICAR160, rats with I/R injury treated with AICAR at the dose 160 mg·kg−1 i.v.; RIR+AICAR500, rats with I/R injury treated with AICAR at the dose 500 mg·kg−1 i.v. Means ± SEM are given, n= 8–19 in each group.
*
P < 0.05 versus sham;
#
P < 0.05 versus RIR.