Figure 1.

Effect of the JNK inhibitor SP600125 on adrenergic contraction of human prostate strips. Contraction of prostate tissue in response to noradrenaline (A) or phenylephrine (B) was determined by myographic measurements, and referred to maximal KCl-induced contraction. SP600125 (50 µM) or the vehicle DMSO was applied 30 min before the first dose of phenylephrine or noradrenaline. Shown are cumulative concentration- response curves for noradrenaline and phenylephrine. Data are means ± SEM from experiments with tissues from n = 6 (A) or n = 7 (B) patients. *P < 0.04, **P < 0.02 for DMSO versus SP600125.