Table 2.
Effects of I2 receptor agonists on the locomotor activity in rats
| Drug dose (mg·kg−1) | Locomotion (% vehicle ± 95% confidence limit) |
|---|---|
| 2-BFI | |
| 10 | 86.2 (65.7, 106.7) |
| 17.8 | 95.7 (50.2, 141.2) |
| Diphenyzoline | |
| 10 | 111.1 (66.1, 156.1) |
| 32 | 83.3 (76.6, 89.9) |
| Phenyzoline | |
| 10 | 126.6 (76.2, 177.0) |
| 32 | 92.7 (71.3, 114.1) |
| Tracizoline | |
| 10 | 159.2 (125.7, 192.8)* |
| 32 | 109.0 (85.4, 132.5) |
| BU224 | |
| 10 | 107.7 (80.9, 134.5) |
| 17.8 | 73.4 (39.7, 107.1) |
| CR4056 | |
| 10 | 71.2 (57.3, 85.0)* |
| 32 | 65.6 (44.8, 86.5)* |
| S22687 | |
| 10 | 269.4 (133.3, 405.5)* |
| 17.8 | 755.4 (429.2, 1081.6)* |
| 32 | 239.1 (152.7, 325.5)* |
*
Indicates data significantly different from saline control.