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. 2012 Jul;166(6):1964–1976. doi: 10.1111/j.1476-5381.2012.01905.x

Figure 5.

Figure 5

Histological examination of PAS stain of ovalbumin-challenged/vehicle-pretreated mice shows significant bronchial mucus production and goblet cell hyper/metaplasia in mice (B) (n = 6) compared with PBS-challenged mice (A) (n = 6). Treatment with Ang-(1–7) (0.3 mg·kg−1; i.p.) (C) (n = 6) resulted in a significant reduction (asterisks) in bronchial mucus production and goblet cell hyper/metaplasia and was similar to PBS vehicle group (A). Treatment with A779 (1 mg·kg−1; i.p.) (D) (n = 6) significantly blocked the Ang-(1–7)-mediated inhibition of bronchial mucus production and goblet cell hyper/metaplasia in mice; (Inline graphic), significant and remarkable bronchial mucus production and goblet cell hyper/metaplasia.