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Kaplan-Meier survival analysis stratified according to depth of tumor invasion. Unlike the American Joint Committee on Cancer (AJCC) T classification, depth of tumor invasion was a strong predictor of long-term outcome. The 5-year survival rates of patients with distal cholangiocarcinoma lesions measuring <5 mm, 5–12 mm, and >12 mm were 69.3%, 21.5%, and 4.1%, respectively (P < .0001).
