Table II.
Univariate analysis of pathologic features affecting patient survival with distal extrahepatic bile duct carcinoma
| Variable | Characteristics | Median survival (month) | 95% confidence interval
|
P value | |
|---|---|---|---|---|---|
| Lower | Upper | ||||
| Sex | Male | 20.2 | 12.2 | 28.2 | .79 |
| Female | 16.6 | 7.8 | 25.4 | ||
| Differentiation | Well | 12.7 | 10.2 | 15.2 | .09 |
| Moderate | 26.0 | 16.2 | 35.8 | ||
| Poor | 11.3 | 7.0 | 15.5 | ||
| T classification | T1 | 40.1 | 30.2 | 51.4 | .17 |
| T2 | 14.8 | 0 | 52.5 | ||
| T3 | 16.5 | 11.3 | 21.7 | ||
| T4 | 20.2 | 9.7 | 30.7 | ||
| Nodal metastasis | Absent | 40.8 | 25.6 | 55.9 | .003 |
| Present | 15.0 | 11.9 | 18.1 | ||
| Resection margin | Negative | 18.9 | 11.1 | 26.7 | .23 |
| Positive | 19.0 | 7.3 | 30.7 | ||
| Perineural invasion | Absent | 31.4 | 15.3 | 47.6 | .001 |
| Present | 14.7 | 10.9 | 18.5 | ||
| Vascular invasion | Absent | 24.5 | 12.0 | 37.0 | <.0001 |
| Present | 12.1 | 8.0 | 16.2 | ||
| Pancreas invasion | Absent | 40.8 | 32.9 | 48.7 | .02 |
| Present | 18.7 | 12.5 | 24.9 | ||
| Duodenal invasion | Absent | 18.7 | 8.1 | 29.4 | .50 |
| Present | 20.2 | 9.7 | 30.7 | ||
| Depth of invasion | <5 mm | * | – | – | <.0001 |
| 5–12 mm | 28.9 | 18.3 | 39.5 | ||
| >12 mm | 12.9 | 10.5 | 15.5 | ||
*
Cannot be calculated because 78.6% of patients were alive.